Uncovering Negative Results: Introducing an Open Access Journal “Journal of Pharmaceutical Negative Results”
نویسندگان
چکیده
Drug discovery nowadays is a highly innovative process by which new drugs are discovered and/or designed. It is expected that in the year 2010, at least 50% of all new approved drugs will come from the biopharmaceutical sector. The discovery and validation process is mostly carried out by new innovative and medium-sized companies. But, despite advances in technology and greater understanding of biological systems, drug discovery is still a lengthy process. Specialized drug discovery companies need an ideal business climate, that is, political, economic and social conditions, to be able to cope with the entrepreneurial risks of drug development.
منابع مشابه
Determination of the largest pit with the non-negative net profit in the open pit mines
The determination of the Ultimate Pit Limit (UPL) is the first step in the open pit mine planning process. In this stage that parts of the mineral deposit that are economic to mine are determined. There are several mathematical, heuristic and meta-heuristic algorithms to determine UPL. The optimization criterion in these algorithms is maximization of the total profit whilst satisfying...
متن کاملUncovering the Influence of EFL Students’ Perfectionism and Anxiety on their Willingness to Communicate in Language Classes
The study aims at investigating the influence of English as a Foreign Language (EFL) students' perfectionism and anxiety on their Willingness to Communicate (WTC) in EFL classes. To do so, a set of questionnaires, namely “Willingness To Communicate” (MacIntyre, et al., 2001), “Foreign Language Classroom Anxiety” (Horwitz, et al., 1986) and “Multidimensional Perfectionism Scales” (Hewitt & Flet...
متن کاملWound Healing Potential of Intermittent Negative Pressure under Limited Access Dressing in Burn Patients: Biochemical and Histopathological Study
BACKGROUND Malondialdehyde (MDA) is an oxidant that causes damage to membranes, DNA, proteins, and lipids at the cellular level. Antioxidants minimize the effects of oxidants and thus help in formation of healthy granulation tissues with higher level of hydroxyproline and total protein. This study compared the effect of limited access dressing (LAD) with conventional closed dressing biochemica...
متن کاملSuperficial Burn Wound Healing with Intermittent Negative Pressure Wound Therapy Under Limited Access and Conventional Dressings
BACKGROUND Thermal injury is associated with several biochemical and histopathological alteration in tissue. Analysis of these objective parameters in research and clinical field are common to determine healing rate of burn wound. Negative pressure wound therapy has been achieved wide success in treating chronic wounds. This study determines superficial burn wound healing with intermittent n...
متن کاملEvaluation of Factors Affecting Prescribing Behaviors, in Iran Pharmaceutical Market by Econometric Methods
Abstract Prescribing behavior of physicians affected by many factors. The present study is aimed at discovering the simultaneous effects of the evaluated factors (including: price, promotion and demographic characteristics of physicians) and quantification of these effects. In order to estimate these effects, Fluvoxamine (an antidepressant drug) was selected and the model was figured out by pan...
متن کامل